05965720 is referenced by 189 patents and cites 7 patents.

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more stable duplexes than phosphodiesters with complementary DNA and particularly RNA strands. Further, the phosphoramidate analogs can also form stable triplexes with double-stranded DNA target, where under similar conditions parent phosphodiester compounds failed to do so.

Title
Oligonucleotide N3.fwdarw.P5 phosphoramidates
Application Number
210505
Publication Number
5965720
Application Date
January 10, 1997
Publication Date
October 12, 1999
Inventor
Jer kang Chen
Palo Alto
CA, US
Ronald G Schultz
Urbana
MO, US
Sergei M Gryaznov
San Mateo
CA, US
Agent
Vincent M Powers
John D Mendlein
Stephen C Macevicz
Assignee
Lynx Therapeutics
CA, US
IPC
C12Q 1/68
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