05962419 is referenced by 9 patents and cites 110 patents.

Methods of use of compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds provided for use in the methods are those of the formula: ##STR1## in which R.sub.1 is preferably 2-methylpropenyl, 2-butenyl, cyclohexyl or cyclohexylmethyl; R.sub.2, R.sub.4, and R.sub.8 are each preferably independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; Q is preferably --C(O)--; R.sub.B is preferably iso-butyl; R.sub.A is --(T).sub.m --(D).sub.m --R.sub.1, in which T is preferably oxygen or NH, m is 0 or 1, and D is preferably C.sub.1-4 alkyl or C.sub.2-4 alkenyl; and X is preferably an aldehyde, .alpha.-ketoester or .alpha.-ketoamide.

Title
Peptide and peptide analog protease inhibitors
Application Number
369422
Publication Number
5962419
Application Date
May 17, 1995
Publication Date
October 5, 1999
Inventor
Steven Lee Wagner
Del Mar
CA, US
Robert Steven Siegel
San Diego
CA, US
Blake Alan Rowe
San Diego
CA, US
Benito Munoz
San Diego
CA, US
Elisabeth Albrecht
San Diego
CA, US
Ian Alexander McDonald
San Diego
CA, US
Agent
Stephanine L Heller Ehrman White & McAuliffe Seidman
Assignee
SIBIA Neurosciences
CA, US
IPC
A61K 38/00
View Original Source