05962246 is referenced by 31 patents and cites 1 patents.

The invention provides the DNA and amino acid sequence of dUTPase, an enzyme which is essential for life and which is increased during periods of cellular proliferation. The human form of the dUTPase enzyme has been found to have two isoforms, a nuclear and a mitochondrial isoform. Methods of determining the proliferation status of a cell, efficacy of antineoplastic compounds, and response to therapy with antineoplastic compounds, using cellular levels of dUTPase is disclosed. A kit containing the necessary reagents for the determination of dUTPase is also disclosed.

Title
dUTPase, its isoforms, and diagnostic and other uses
Application Number
8/824405
Publication Number
5962246
Application Date
March 26, 1997
Publication Date
October 5, 1999
Inventor
Salvatore J Caradonna
Voorhees
NJ, US
Frank Lynch
Marlton
NJ, US
Robert D Ladner
Haddonfield
NJ, US
Agent
Dechert Price & Rhoads
Assignee
The University of Medicine and Dentistry of New Jersey
NJ, US
IPC
C12N 9/16
C12N 9/14
C12Q 1/00
C12Q 1/42
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