05951458 is referenced by 74 patents and cites 51 patents.

A method for inhibiting restenosis including local application of an oxidizing agent to blood vessel walls. Preferred oxidizing agents include peroxides, most preferably hydrogen peroxide. Oxidizing agents can be delivered utilizing drug delivery balloon catheters. Preferred delivery catheters include an inflatable balloon having a perfusion lumen therethrough to allow for longer application periods. Oxidizing agents can be delivered either alone or in conjunction with radiation or stent delivery. One method includes local delivery of 0.1% hydrogen peroxide to a dilated stenosis wall for a period of 10 minutes at a rate of 0.5 cc per minute.

Title
Local application of oxidizing agents to prevent restenosis
Application Number
608655
Publication Number
5951458
Application Date
August 1, 1997
Publication Date
September 14, 1999
Inventor
Michael J Urick
Rogers
MN, US
Mark T Ungs
St. Paul
MN, US
Dachuan Yang
Plymouth
MN, US
Lixiao Wang
Maple Grove
MN, US
Roger N Hastings
Maple Grove
MN, US
Agent
Crompton Seager & Tufte
Assignee
SciMed Life Systems
MN, US
IPC
A61M 5/00
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