05947921 is referenced by 211 patents and cites 64 patents.

Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by providing chemical enhancers which increase the solubility of the compound to be transported and/or lipid bilayer solubility, and/or additional driving forces for transport, such as mechanical or osmotic pressure, magnetic fields, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities and other forces or concentrations than that required if each means of enhancing transport is used individually.

Title
Chemical and physical enhancers and ultrasound for transdermal drug delivery
Application Number
8/574377
Publication Number
5947921
Application Date
December 18, 1995
Publication Date
September 7, 1999
Inventor
Joseph Kost
Omer
IL
Michael Pishko
Arlington
MA, US
Robert S Langer
Newton
MA, US
Daniel Blankschtein
Brookline
MA, US
Samir S Mitragotri
Cambridge
MA, US
Mark E Johnson
Allston
MA, US
Agent
Arnall Golden & Gregory
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61B 5/00
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