05942400 is referenced by 99 patents and cites 5 patents.

Compositions comprising a novel protease capable of cleaving .beta.-amyloid precursor protein (APP) on the amino-terminal side of the .beta.-amyloid peptide therein are provided. The protease is designated .beta.-secretase. Reaction systems comprising .beta.-secretase may be used in screening assays to monitor .beta.-secretase modulated cleavage of APP and to identify .beta.-secretase inhibitors, wherein the .beta.-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of .beta.-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

Title
Assays for detecting .beta.-secretase
Application Number
480498
Publication Number
5942400
Application Date
June 7, 1996
Publication Date
August 24, 1999
Inventor
Sukanto Sinha
San Francisco
CA, US
Kirsten L Jacobson Croak
San Bruno
CA, US
John P Anderson
San Francisco
CA, US
Agent
Townsend & Townsend & Crew
Assignee
Elan Pharmaceuticals
CA, US
IPC
G01N 33/53
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