05939598 is referenced by 541 patents and cites 11 patents.

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci.

Title
Method of making transgenic mice lacking endogenous heavy chains
Application Number
466008
Publication Number
5939598
Application Date
July 30, 1992
Publication Date
August 17, 1999
Inventor
Aya Jakobovits
Menlo Park
CA, US
Raju Kucherlapati
Darien
CT, US
Agent
Fish & Neave
Agent
Jane T Gunnison Esq
James F Haley Jr Esq
Assignee
Abgenix
CA, US
IPC
C12N 15/09
A61K 48/00
View Original Source