A portable multiple-vital signs monitor unit of the described apparatus is of ultra-light weight, e.g. less than one pound. In its preferred embodiment, the portable unit takes the form of a right parallelepiped enclosure the volume of which is only approximately 40 in.sup.3 having operator display and control panels and body lead jacks on its face and periphery, respectively, and providing wireless remote full-function communication with an in situ base unit with which the portable monitor may optionally be docked. The base unit communicates via a single telephone line with a remote, typically central location including a host computer and a health care provider, preferably via concurrent voice and data transmission. In its preferred embodiment, the invented apparatus includes in the portable unit the capability for diagnostic quality ECG and pulse oximetry monitoring and in its base unit the capability diagnostic quality blood pressure monitoring.