05876452 is referenced by 164 patents and cites 63 patents.

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts of bioactive agent are released, thereby promoting differentiation of cells. Method of making material includes steps of applying vacuum temperature and consession to form pores. Implant material may be adapted for one phase implant (e.g., for bone or cartilage) or for two phase layered implant (e.g., for cartilage layer on top of bone layer).

Title
Biodegradable implant
Application Number
837401
Publication Number
5876452
Application Date
May 30, 1995
Publication Date
March 2, 1999
Inventor
Barbara D Boyan
San Antonio
TX, US
Kyriacos A Athanasiou
San Antonio
TX, US
Agent
Greenlee Winner and Sullivan P C
Assignee
Board of Regents University of Texas System
TX, US
IPC
A61F 2/02
A61F 2/28
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