05874064 is referenced by 248 patents and cites 25 patents.

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

Title
Aerodynamically light particles for pulmonary drug delivery
Application Number
655570
Publication Number
5874064
Application Date
October 29, 1996
Publication Date
February 23, 1999
Inventor
Robert S Langer
Newton
MA, US
Abdell Aziz Ben Jebria
State College
PA, US
Justin Hanes
Baltimore
MD, US
Noah Lotan
Haifa
IL
Jeffrey S Hrkach
Somerville
MA, US
Giovanni Caponetti
Piacenza
IT
David A Edwards
State College
PA, US
Agent
Arnall Golden & Gregory
Assignee
The Penn State Research Foundation
PA, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/12
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