05873904 is referenced by 865 patents and cites 34 patents.

A silver implantable medical device 29 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicant material utilized with the implantable stent.

Title
Silver implantable medical device
Application Number
484532
Publication Number
5873904
Application Date
February 24, 1997
Publication Date
February 23, 1999
Inventor
William D Voorhees III
West Lafayette
IN, US
Joseph W Roberts
Minneapolis
MN, US
Thomas G Kozma
West Lafayette
IN, US
Thomas A Osborne
Bloomington
IN, US
Neal E Fearnot
West Lafayette
IN, US
Brian L Bates
Bloomington
IN, US
Anthony O Ragheb
West Lafayette
IN, US
Agent
Richard J Godlewski
Assignee
MED Institute
IN, US
Cook Incorporated
IN, US
IPC
A61F 2/06
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