05872101 is referenced by 11 patents and cites 98 patents.

Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): ##STR1## in which R.sub.1 is preferably 2-methyl propene, 2-butene, norleucine; R.sub.2, R.sub.4, and R.sub.8 are each independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; R.sub.8 is preferbly iso-butyl; R.sub.A =--(T).sub.m --(D).sub.m --R.sub.1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C.sub.3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.

Title
Methods of treating neurodegenerative disorders using protease inhibitors
Application Number
369422
Publication Number
5872101
Application Date
May 18, 1995
Publication Date
February 16, 1999
Inventor
Elisabeth Albrecht
San Diego
CA, US
Ian A McDonald
San Diego
CA, US
Benito Munoz
San Diego
CA, US
Agent
Stephanie L Seidman Heller Ehrman White & McAuliffe
Assignee
Sibia Neurosciences
CA, US
IPC
A61K 38/00
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