05869127 is referenced by 310 patents and cites 40 patents.

Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.

Title
Method of providing a substrate with a bio-active/biocompatible coating
Application Number
392141
Publication Number
5869127
Application Date
June 18, 1997
Publication Date
February 9, 1999
Inventor
Sheng Ping Zhong
Northboro
MA, US
Agent
Hoffman & Baron
Assignee
Boston Scientific Corporation
MA, US
IPC
A61L 33/00
B05D 3/00
B05D 3/10
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