05858351 is referenced by 62 patents and cites 11 patents.

The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved.

Title
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
Application Number
8/588355
Publication Number
5858351
Application Date
January 18, 1996
Publication Date
January 12, 1999
Inventor
Gary J Kurtzman
Menlo Park
CA, US
Barry J Byrne
Baltimore
MD, US
Paul D Kessler
Baltimore
MD, US
Gregory M Podsakoff
Fullerton
CA, US
Agent
Robins & Associates
Assignee
Johns Hopkins University
MD, US
Avigen
CA, US
IPC
C12N 15/00
C12N 5/00
A61K 48/00
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