05854226 is referenced by 22 patents and cites 14 patents.

A pharmaceutical composition for oral administration for the treatment of acute pain and inflammation comprises an inclusion complex of a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof and a cyclodextrin, and a physiologically acceptable alkali agent selected from the group consisting of alkali and alkaline earth metal carbonates, bicarbonates, phosphates and hydroxides, and water soluble amines, in an amount equivalent to between 2 and 30 molar equivalents inclusive of the non-steroidal anti-inflammatory drug, the alkali agent being capable of forming an alkaline diffusion layer around the composition in the grastrointestinal tract.

Title
Pharmaceutical composition
Application Number
8/849059
Publication Number
5854226
Application Date
May 15, 1997
Publication Date
December 29, 1998
Inventor
Michiel C B Van Oudtshoorn
Pretoria
ZA
Douglas G M Nicholson
Port Elizabeth
ZA
Lueta A Glintenkamp
Port Elizabeth
ZA
Lawrence J Penkler
Port Elizabeth
ZA
Agent
Pillsbury Madison & Sutro
Assignee
Farmarc Nederland
NL
IPC
A61K 31/19
A61K 31/715
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