05852041 is referenced by 91 patents and cites 13 patents.

In accordance with the present invention, there provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors, and are useful for a variety of therapeutic applications, such as the treatment of Alzheimer's disease and other disorders involving memory loss and/or dementia (including AIDS dementia); disorders of attention and focus (such as attention deficit disorder); disorders of extrapyramidal motor function such as Parkinson's disease, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiety and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation of food intake, including bulimia and anorexia; disorders of nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardia arrhythmias, comedication in surgical procedures, and the like.

Title
Substituted pyridines useful as modulators of acethylcholine receptors
Application Number
419597
Publication Number
5852041
Application Date
June 7, 1995
Publication Date
December 22, 1998
Inventor
Jean Michel Vernier
San Diego
CA, US
Nicholas D Cosford
La Jolla
CA, US
Agent
Stephen E Gray Care Ware & Freidenrich Reiter
Assignee
SIBIA Neurosciences
CA, US
IPC
C07D 213/02
A61K 31/44
View Original Source