05846937 is referenced by 40 patents and cites 7 patents.

Agonists of the incretin GLP-1 have been found to have a sedative or anxiolytic effect on the mammalian central nervous system. Additionally, exendin has been found to have an independent sedative effect on the mammalian central nervous system. Conversely, antagonists of GLP-1 increase nervous system activity. The invention relates, in one aspect, to the use of GLP-1 agonists and antagonists to affect the arousal state of the mammalian central nervous system. The invention also relates to novel transgenic mammals in which the GLP-1 receptor gene has been disrupted.

Title
Method of using exendin and GLP-1 to affect the central nervous system
Application Number
8/811066
Publication Number
5846937
Application Date
March 3, 1997
Publication Date
December 8, 1998
Inventor
Daniel J Drucker
Toronto
CA
Agent
Pennie & Edmonds
Assignee
1149336 Ontario
CA
IPC
C07K 14/605
A61K 38/26
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