05846835 is referenced by 24 patents and cites 23 patents.

The invention relates to a method of making a laminated substrate for use in an immunodiagnostic device and a machine or apparatus for marking the substrate with reagent. The method of forming the laminated substrate creates a rollable chromatographic medium. The chromatographic medium can be biphasic or multiphasic. The biphasic chromatographic medium comprises a capture medium precast onto a plastic backing and a release medium. The release and capture media are bonded to a liner material such as a plastic film. The multiphasic chromatographic medium comprises a capture medium precast onto a plastic backing, a release medium, and a sample absorbent medium. The capture medium, the release medium and the sample absorbent medium are disposed on a liner material such as a plastic film. The biphasic and multiphasic laminates are prepared for use as immunoassays by a specially adapted machine or apparatus. The machine includes a leader, an unwind system, a reagent dispensing system, a substrate reject marking system, a drying system, and a rewind system. In one exemplary embodiment, the machine applies four reagents to the substrate. The particular reagents used in the machine will vary depending upon the immunoassay to be performed.

Title
Manufacturing method for laminated immunodiagnostic test device
Application Number
434342
Publication Number
5846835
Application Date
August 7, 1997
Publication Date
December 8, 1998
Inventor
Albert R Nazareth
Mercerville
NJ, US
Glenn W Thomsen
Cream Ridge
NJ, US
Fredrick P Sisbarro
Wayne
NJ, US
Agent
Testa Hurwitz & Thibeault
Assignee
Carter Wallace
NY, US
IPC
G01N 33/48
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