05846708 is referenced by 383 patents and cites 47 patents.

A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

Title
Optical and electrical methods and apparatus for molecule detection
Application Number
794036
Publication Number
5846708
Application Date
April 23, 1992
Publication Date
December 8, 1998
Inventor
Rajender Singh Varma
The Woodlands
TX, US
Michael E Hogan
The Woodlands
TX, US
Mitch D Eggers
The Woodlands
TX, US
Barry E Burke
Lexington
MA, US
Richard H Mathews
Chelmsford
MA, US
Dennis D Rathman
Ashland
MA, US
Bernard B Kosicki
Acton
MA, US
R Allen Murphy
Boxboro
MA, US
Daniel J Ehrlich
Lexington
MA, US
Mark A Hollis
Concord
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
Assignee
Massachusetts Institiute of Technology
MA, US
IPC
C12Q 1/68
View Original Source