05842477 is referenced by 459 patents and cites 21 patents.

The present invention relates to methods of making and/or repairing cartilage in vivo comprising implanting into a patient, at a site of cartilage damage or loss, a biocompatible, non-living three-dimensional scaffold or framework structure in combination with periosteal/perichondrial tissue that can be used to hold the scaffold in place and provides a source of chondrocyte progenitor cells, chondrocytes and other stromal cells for attachment to the scaffold in vivo. In addition, a preparation of cells that can include chondrocytes, chondrocyte progenitor cells or other stromal cells is administered, either before, during or after implantation of the scaffold and/or the periosteal perichondrial tissue; the cells are administered directly into the site of the implant in vivo and promote the induction of factors that enhance chondrogenesis and the migration of chondrocytes, progenitor cells and other stromal cells from the adjacent in vivo environment into the scaffold for the production of new cartilage at the site of implantation.

Title
Method for repairing cartilage
Application Number
8/604284
Publication Number
5842477
Application Date
February 21, 1996
Publication Date
December 1, 1998
Inventor
Jane Willoughby
Solana Beach
CA, US
Gail K Naughton
Del Mar
CA, US
Agent
Pennie & Edmonds
Assignee
Advanced Tissue Sciences
CA, US
IPC
A61F 2/08
A61B 19/00
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