05837282 is referenced by 46 patents and cites 14 patents.

Novel methods are provided for loading a weakly basic drug into liposomes utilizing an electoneutral transport system. In these methods, ionophores are utilized with liposomes having a metal ion gradient to facilitate the exchange of metal ions for protons. The transported metal ion will, in some embodiments, be complexed with a chelating agent which is present in the external media.

Title
Ionophore-mediated liposome loading
Application Number
8/741622
Publication Number
5837282
Application Date
October 30, 1996
Publication Date
November 17, 1998
Inventor
Nancy Boman
Surrey
CA
Elisabeth Maurer
Vancouver
CA
Johanna M Leenhouts
Vancouver
CA
Maurer Norbert
Vancouver
CA
Kim Wong
Vancouver
CA
Pieter R Cullis
Vancouver
CA
David B Fenske
Surrey
CA
Agent
Townsend and Townsend and Crew
Assignee
University of British Columbia
CA
IPC
A61K 9/137
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