05795589 is referenced by 46 patents and cites 14 patents.

A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a tranamembrane pH gradient. Using this technique, trapping efficiencies approach 100%, and liposomes may be loaded with drug immediately prior to use, eliminating stability problem related to drug retention in the liposomes. Drug:lipid ratios employed are about 3-80 fold higher than for traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. An assay method to determine free antineoplastic agents in a liposome preparation is also disclosed.

Title
Liposomal antineoplastic agent compositions
Application Number
22154
Publication Number
5795589
Application Date
February 5, 1997
Publication Date
August 18, 1998
Inventor
George N Mitilenes
Washington
NJ, US
Richard S Ginsberg
Jamesburg
NJ, US
Pieter R Cullis
Vancouver
CA
Marcel B Bally
Vancouver
CA
Lawrence D Mayer
Vancouver
CA
Agent
Kenneth B Rubin
Rosanne Goodman
Assignee
The Liposome Company
NJ, US
IPC
A61K 9/133
A61K 9/127
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