05788979 is referenced by 406 patents and cites 4 patents.

A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from such contact. A biodegradable material of liquid state compatible with the blood and tissue of the human body is prepared, and an anti-coagulant drug is incorporated into the liquid state of the biodegradable material to form a liquid coating material. The liquid coating material is adhesively applied to a surface of the biomaterial in a substantially continuous overlying layer having a formulation, pattern and thickness selected according to the period of time over which the coating material is to perform its anti-coagulant action. Thereafter the coating material is dried to a layer thickness less than about 100 microns for continuous disintegration thereof as a function of time when the layer is in contact with flowing blood. The method is utilized in an exemplary embodiment in which the biomaterial is a vascular stent.

Title
Biodegradable coating with inhibitory properties for application to biocompatible materials
Application Number
278806
Publication Number
5788979
Application Date
February 10, 1997
Publication Date
August 4, 1998
Inventor
Axel Stemberger
Neubiberg
DE
Eckhard Alt
Ottobrunn
DE
Assignee
Inflow Dynamics
VA, US
IPC
A61F 2/00
View Original Source