05767125 is referenced by 92 patents and cites 13 patents.

This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of the bimodally-acting opioid agonist. The method of the present invention comprises administering to a subject an analgesic or sub-analgesic amount of a bimodally-acting opioid agonist such as morphine and an amount of an excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of the bimodally-acting opioid agonist and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of the bimodally-acting opioid agonist.

Title
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
Application Number
947690
Publication Number
5767125
Application Date
December 3, 1996
Publication Date
June 16, 1998
Inventor
Ke fei Shen
Flushing
NY, US
Stanley M Crain
Leonia
NJ, US
Agent
Amster Rothstein & Ebenstein
Assignee
Albert Einstein College of Medicine of Yeshiva University a Division of Yeshiva University
NY, US
IPC
A61K 31/14
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