05752515 is referenced by 81 patents and cites 15 patents.

Image-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging, to confirm the location of that change. A compound, e.g., a neuropharmaceutical, in the patient's bloodstream is delivered to the confirmed location by applying ultrasound to effect opening of the blood-brain barrier at that location and, thereby, to induce uptake of the compound there.

Title
Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
Application Number
8/711289
Publication Number
5752515
Application Date
August 21, 1996
Publication Date
May 19, 1998
Inventor
Kullervo Hynynen
Medfield
MA, US
Ferenc A Jolesz
Brookline
MA, US
Agent
Choate Hall & Stewart
Assignee
Brigham & Women s Hospital
MA, US
IPC
A61B 5/00
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