05749968 is referenced by 87 patents and cites 43 patents.

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Title
Device for priming for improved adherence of gels to substrates
Application Number
24657
Publication Number
5749968
Application Date
June 7, 1995
Publication Date
May 12, 1998
Inventor
David J Nedder
Attleboro
MA, US
George Selecman
Marblehead
MA, US
Dean M Pichon
Concord
MA, US
Thomas S Bromander
Andover
MA, US
John C Spiridigliozzi
Dedham
MA, US
Marc Alan Levine
Sharon
MA, US
David A Melanson
Hudson
NH, US
Agent
Wolf Greenfield & Sacks P C
Assignee
Focal
MA, US
IPC
B05C 5/00
View Original Source