05741248 is referenced by 207 patents and cites 46 patents.

A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic fluid through the cryoprobe, the cryogenic fluid causing an ice ball to form in a vicinity around the cryoprobe, wherein the ice ball obliterates at least a portion of the lesion. The fluorochemical liquid is utilized to augment the cryosurgical procedure and is perfused or injected into and/or around the lesioned site prior and/or during the application of a cryoprobe to the site. In one embodiment of the invention, the fluorochemical liquid acts as a contrast agent to enhance real-time medical imaging of the lesioned area and modifies the environment in and around the lesioned area. In another embodiment of the invention, the fluorochemical liquid augments cryosurgical procedures by controlling the size and shape of ice balls formed during the cryosurgical procedures. In this embodiment, a fluorochemical liquid with a properly chosen thermal conductivity and freezing point is utilized. Depending on the thermal properties chosen, the liquid either augments freezing of the target area and/or promotes thermal conduction to freeze larger areas, or limits the freezing of the target area and reduces thermal conduction. In a non-cryoprobe embodiment, the liquid is cooled to a temperature below the freezing point of the biological tissue. The cooled liquid is then infused into or around the cystic lesion to produce ablation.

Title
Fluorochemical liquid augmented cryosurgery
Application Number
8/487386
Publication Number
5741248
Application Date
June 7, 1995
Publication Date
April 21, 1998
Inventor
Marla R Wolfson
Philadelphia
PA, US
Thomas H Shaffer
Lansdowne
PA, US
Robert G Stern
Philadelphia
PA, US
Agent
Seidel Gonda Lavorgna & Monaco PC
Assignee
Temple University of the Commonwealth System of Higher Education
PA, US
IPC
A61B 17/36
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