05738846 is referenced by 126 patents and cites 21 patents.

Interferon-polymer conjugate containing compositions having high levels of retained interferon activity and relatively long circulating lives in vivo are disclosed. The compositions contain a mixture of mono-interferon-polymer conjugates and bis-interferon-polymer conjugates, with both species containing substantially a single polymer strand. The conjugate compositions are prepared by reacting about 1 mole of an interferon with from about 0.125 to about 1 mole of a bis-activated substantially non-antigenic polymer under conditions sufficient to effect covalent conjugation of the interferon and polymer. Methods of treating interferon-susceptible conditions with the compositions of the present invention are also disclosed.

Title
Interferon polymer conjugates and process for preparing the same
Application Number
337567
Publication Number
5738846
Application Date
November 21, 1995
Publication Date
April 14, 1998
Inventor
Carl W Gilbert
Basking Ridge
NJ, US
Richard B Greenwald
Somerset
NJ, US
Agent
Roberts & Mercanti L
Assignee
Enzon
NJ, US
IPC
A61K 38/21
View Original Source