05733925 is referenced by 479 patents and cites 120 patents.

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

Title
Therapeutic inhibitor of vascular smooth muscle cells
Application Number
11669
Publication Number
5733925
Application Date
October 28, 1996
Publication Date
March 31, 1998
Inventor
Peter G Anderson
Brimingham
AL, US
Peter L Weissberg
Cambridge
GB
James C Metcalfe
Cambridge
GB
David J Grainger
Cambridge
GB
John M Reno
Brier
WA, US
Richard A Klein
Lynnwood
WA, US
Lawrence L Kunz
Redmond
WA, US
Agent
Schwegman Lundberg Woessner & Kluth P A
Assignee
NeoRx Corporation
WA, US
IPC
A61K 31/535
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