05731350 cites 40 patents.

Benzenedicarboxylic acid diguanides of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, are useful antiarrhythmic pharmaceuticals having a cardioprotective component, even for the prevention of ischemically induced damage, in particular in the induction of ischemically induced cardiac arrhythmias. As a result of inhibition of the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for the treatment of acute or chronic damage caused by ischemia. Moreover, they are distinguished by potent inhibitory action on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.

Title
Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
Application Number
8/747004
Publication Number
5731350
Application Date
November 7, 1996
Publication Date
March 24, 1998
Inventor
Wolfgang Scholz
Eschborn
DE
Udo Albus
Florstadt
DE
Hans Jochen Lang
Hofheim
DE
Andreas Weichert
Egelsbach
DE
Jan Robert Schwark
Frankfurt
DE
Joachim Brendel
Bad Vilbel
DE
Heinz Werner Kleemann
Bischofsheim
DE
Agent
Finnegan Henderson Farabow Garrett & Dunner L
Assignee
Hoechst Aktiengesellschaft
DE
IPC
C07C 233/67
A61K 31/16
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