05728396 is referenced by 288 patents and cites 12 patents.

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

Title
Sustained delivery of leuprolide using an implantable system
Application Number
595761
Publication Number
5728396
Application Date
January 30, 1997
Publication Date
March 17, 1998
Inventor
Jeremy C Wright
Los Altos
CA, US
Judy A Magruder
Mountain View
CA, US
Scott D Lautenbach
San Mateo
CA, US
Felix A Landrau
Punta Gorda
FL, US
James B Eckenhoff
Los Altos
CA, US
Keith E Dionne
Menlo Park
CA, US
John R Peery
Stanford
CA, US
Agent
Steven F Stone
Mary Ann Dillahunty
Pauline A Clarke
Assignee
Alza Corporation
CA, US
IPC
A61F 9/22
A61F 2/00
A61F 13/00
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