05723287 is referenced by 28 patents and cites 7 patents.

We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.

Title
Recombinant viruses displaying a nonviral polypeptide on their external surface
Application Number
8/381960
Publication Number
5723287
Application Date
May 3, 1995
Publication Date
March 3, 1998
Inventor
Gregory P Winter
Cambridge
GB
Robert E Hawkins
Cambridge
GB
Stephen J Russell
Cambridge
GB
Agent
Kathleen Madden Williams
Assignee
Medical Research Council
GB
IPC
C07H 21/04
C12N 1/00
C12Q 1/68
C12Q 1/70
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