05700485 is referenced by 138 patents and cites 60 patents.

Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a biodegradable polymer degrading significantly within a month, with at least 50% of the polymer degrading into non-toxic residues which are removed by the body within a two week period. Useful polymers include polyanhydrides, polylactic acid-glycolic acid copolymers and polyorthoesters containing a catalyst; polylactic acid-glycolic acid copolymers are preferred. Local anesthetics are incorporated into the polymer using a method that yields a uniform dispersion, preferably solvent casting. Prolonged release is obtained by incorporation of a glucocorticoid into the polymeric matrix or by co-administration of the glucocorticoid with the microspheres. The type of anesthetic and the quantity are selected based on the known pharmaceutical properties of these compounds.

Title
Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
Application Number
943287
Publication Number
5700485
Application Date
May 1, 1995
Publication Date
December 23, 1997
Inventor
Robert S Langer
Newton
MA, US
Charles B Berde
Brookline
MA, US
Agent
Arnall Golden & Gregory
Assignee
Children s Medical Center Corporation
MA, US
IPC
A61K 9/22
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