05693761 is referenced by 692 patents and cites 29 patents.

Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about about 3 .ANG. as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.

Title
Polynucleotides encoding improved humanized immunoglobulins
Application Number
290975
Publication Number
5693761
Application Date
June 7, 1995
Publication Date
December 2, 1997
Inventor
Harold E Selick
Belmont
CA, US
William P Schneider
Mountain View
CA, US
Cary L Queen
Los Altos
CA, US
Agent
Townsend and Townsend and Crew
Assignee
Protein Design Labs
CA, US
IPC
C07H 21/04
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