05684133 is referenced by 15 patents and cites 10 patents.

The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuroblastoma cells, and can also inhibit fibroblast spreading. Such inhibitory proteins include a 35,000 dalton and a 250,000 dalton molecular weight protein and analogs, derivatives, and fragments thereof. The CNS myelin associated inhibitory proteins may be used in the treatment of malignant tumors. The present invention is also directed to antibodies to the CNS myelin associated proteins; such antibodies can be used in the diagnosis and therapies of nerve damage resulting from trauma, infarction, and degenerative disorders of the central nervous system. In a specific embodiment of the invention, monoclonal antibody IN-1 may be used to promote regeneration of nerve fibers over long distances in spinal cord lesions.

Title
Neurite growth regulatory factors, antibodies thereto, and pharmaceutical compositions
Application Number
267941
Publication Number
5684133
Application Date
August 30, 1989
Publication Date
November 4, 1997
Inventor
Pierenrico W Caroni
Zurich
CH
Martin E Schwab
Zurich
CH
Agent
Pennie & Edmonds
Assignee
Erziehungsdirektion of the Canton Zurich
CH
IPC
C07K 16/22
C07K 14/48
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