05680858 is referenced by 401 patents and cites 9 patents.

A method for in vivo determination of the concentration in a body fluid of metabolically significant substance comprises storing of a needle with a sensor in a liquid-filled ampoule, brief insertion of the needle into a patient, recording of the output signal from the sensor, withdrawal of the needle, and calculation of the concentration looked for on the basis of the recorded signals. The method is preformed using an apparatus comprising a needle (5) with a sensor (6), an ampoule (1) containing a solution (2) and closed by two membranes (3, 4). The needle (5) is stored with its sensor (6) in the solution. The apparatus further comprises a mechanical unit for driving the needle (5) to protrude from the ampoule for a set moment, and an electronic unit storing the output signal from the sensor (6) and performing calculations on the basis of the stored signal values. The needle with its sensor (6) and the ampoule with the solution (2) are independent disposable parts mounted in a durable part containing the mechanical and electronic parts.

Title
Method and apparatus for in vivo determination of the concentration in a body fluid of metabolically significant substances
Application Number
8/448351
Publication Number
5680858
Application Date
July 6, 1995
Publication Date
October 28, 1997
Inventor
Thomas Munk Plum
Skodsborg
DK
Henrik Ege
Frederiksberg
DK
Henrik Egesborg Hansen
Hellerup
DK
Agent
Elias J Lambiris Esq
Steve T Zelson Esq
Assignee
Novo Nordisk
DK
IPC
A61B 5/05
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