05670338 is referenced by 4 patents and cites 2 patents.

Disclosed are (1) a Xenopus laevis bone morphogenetic protein (BMP), (2) a DNA comprising a DNA segment coding for a Xenopus laevis BMP, (3) a transformant bearing a DNA comprising a DNA segment coding for a Xenopus laevis BMP and (4) a method for preparing the Xenopus laevis BMP which comprises culturing the described in (3), producing and accumulating the protein in a culture, and collecting the protein thus obtained. Cells transinfected or transformed with the DNA allow large amounts of the Xenopus laevis BMP mature peptides to be produced, which causes the advantageous production of the peptides, which promote the synthesis of proteoglycan and can also be utilized for analysis of the mechanism of organism, particularly human bone-cartilage morphogenetic reaction, and as therapeutic agents for osteoporosis.

Title
DNA encoding bone morphogenetic proteins, host cells transformed there by, and uses thereof
Application Number
577892
Publication Number
5670338
Application Date
May 31, 1995
Publication Date
September 23, 1997
Inventor
Yukio Kato
Osaka
JP
Naoto Ueno
Tsukuba
JP
Kazuo Murakami
Tsukuba
JP
Agent
Ronald I Eisenstein
David G Conlin
Assignee
Chichibu Onoda Cement
JP
Takeda Chem
JP
IPC
C12N 15/00
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