05643580 is referenced by 59 patents and cites 7 patents.

The invention involves using a plasma to functionalize a surface of medical devices such as catheters, particularly intracardial catheters, with covalently bound thermochemically reactive groups. The surface is further contacted with a bioactive agent, particularly antithrombogenic coatings, which is thermochemically covalently coupled to the reactive group to form a therapeutically effective coating. The selected bioactive agent is then covalently bound to the surface by thermochemical reaction with the surface reactive groups. In another embodiment, the functionalizing step comprises contacting the surface with a Langmuir-Blodgett film comprising an amphipathic compound and a bioactive agent and using a plasma to covalently crosslink the Langmuir-Blodgett film to the medical device surface and to the bioactive agent. Medical devices prepared by the subject methods are also provided.

Title
Biocompatible coating, medical device using the same and methods
Application Number
8/324413
Publication Number
5643580
Application Date
October 17, 1994
Publication Date
July 1, 1997
Inventor
Raj Subramaniam
Fremont
CA, US
Agent
Flehr Hohbach Test Albritton & Herbert
Assignee
Surface Genesis
CA, US
IPC
B05D 3/06
A61K 41/00
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