05637469 is referenced by 669 patents and cites 24 patents.

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

Title
Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
Application Number
877702
Publication Number
5637469
Application Date
November 30, 1994
Publication Date
June 10, 1997
Inventor
Jay N Zemel
Jenkintown
PA, US
Larry J Kricka
Berwyn
PA, US
Peter Wilding
Paoli
PA, US
Agent
Dann Dorfman Herrell and Skillman
Assignee
Trustees of the University of Pennsylvania
PA, US
IPC
G01N 33/569
G01N 33/558
G01N 33/551
G01N 33/43
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