05635517 is referenced by 185 patents and cites 2 patents.

1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines substituted with amino in the benzo ring reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline.

Title
Method of reducing TNF.alpha. levels with amino substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxo-and 1,3-dioxoisoindolines
Application Number
8/690258
Publication Number
5635517
Application Date
July 24, 1996
Publication Date
June 3, 1997
Inventor
Roger S C Chen
Edison
NJ, US
David I Stirling
Branchburg
NJ, US
George W Muller
Bridgewater
NJ, US
Agent
Mathews Collins Shepherd & Gould P A
Assignee
Celgene Corporation
NJ, US
IPC
C07D 401/04
A61K 31/445
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