Pharmaceutically active ceramide-related compounds United States Patent 05631394

05631394 is referenced by 35 patents and cites 13 patents.

This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --CH(OH)CH(OH)--; Z.sup.1 is OH or a conversion-inhibiting group; Z.sup.2 is a conversion-inhibiting group; Y.sup.2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y.sup.3 is H or a group having the formula --C(O)R.sup.2 or --S(O).sub.2 R.sup.2 ; R.sup.2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z.sup.2 is an amino, R.sup.2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain.

Title
Pharmaceutically active ceramide-related compounds
Application Number
190295
Publication Number
5631394
Application Date
February 2, 1995
Publication Date
May 20, 1997
Inventor
Andrew S Janoff
Yardley
PA, US
Imran Ahmad
Plainsboro
NJ, US
Eric Mayhew
Monmouth Junction
NJ, US
Yong Wei
Branchburg
NJ, US
Agent
Kenneth B Rubin
Assignee
The Liposome Company
NJ, US
IPC
A61K 31/13
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Citations: 35 (view full list)

  1. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of the University of Michigan, Harness Dickey & Pierce, April 18, 2000: US06051598 (72 worldwide citation)
  2. James A Shayman, Norman S Radin: Amino ceramide--like compounds and therapeutic methods of use. The Regents Of The University Of Michigan, Harness Dickey & Pierce, June 29, 1999: US05916911 (56 worldwide citation)
  3. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of the University of Michigan, Harness Dickey & Pierce, February 29, 2000: US06030995 (52 worldwide citation)
  4. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of The University of Michigan, Harness Dickey & Pierce, August 31, 1999: US05945442 (48 worldwide citation)
  5. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of University of Michigan, Harness Dickey & Pierce, September 14, 1999: US05952370 (48 worldwide citation)
  6. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of the University of Michigan, Harness Dickey & Pierce, July 3, 2001: US06255336 (33 worldwide citation)
  7. James A Shayman, Norman S Radin: Amino ceramide-like compounds and therapeutic methods of use. The Regents of the University of Michigan, Harness Dickey & Pierce, March 21, 2000: US06040332 (28 worldwide citation)
  8. Roger A Sabbadini: Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor. Medlyte SDSU Heart Institute, Daniel M Chambers, Biotechnology Law Group, April 19, 2005: US06881546 (25 worldwide citation)
  9. Roger A Sabbadini: Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor. Medlyte, Foley & Lardner, February 22, 2005: US06858383 (25 worldwide citation)
  10. Roger A Sabbadini: Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation. Lpath Therapeutics, BioTechnology Law Group, Daniel M Chambers, January 30, 2007: US07169390 (19 worldwide citation)

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