05629384 is referenced by 178 patents and cites 26 patents.

Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein -Z-X-Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.

Title
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
Application Number
8/243869
Publication Number
5629384
Application Date
May 17, 1994
Publication Date
May 13, 1997
Inventor
Paolo Ferruti
Milan
IT
Elisabetta Ranucci
Brescia
IT
Luciana Sartore
Marano Vic.
IT
Paolo Caliceti
Padua
IT
Oddone Schiavon
Padua
IT
Francesco M Veronese
Padua
IT
Agent
Bell Seltzer Park & Gibson P A
Assignee
Consiglio Nazionale delle Ricerche
IT
IPC
C08F 20/60
C08F 20/58
C08F 8/00
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