05626862 is referenced by 223 patents and cites 12 patents.

A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.

Title
Controlled local delivery of chemotherapeutic agents for treating solid tumors
Application Number
8/284341
Publication Number
5626862
Application Date
August 2, 1994
Publication Date
May 6, 1997
Inventor
Abraham J Domb
Efrat
IL
Robert S Langer
Newton
MA, US
Henry Brem
Lutherville
MD, US
Agent
Arnall Golden & Gregory
Assignee
The Johns Hopkins University
MD, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 31/335
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