05618563 is referenced by 152 patents and cites 60 patents.

An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation.

Title
Biodegradable polymer matrices for sustained delivery of local anesthetic agents
Application Number
943287
Publication Number
5618563
Application Date
September 10, 1993
Publication Date
April 8, 1997
Inventor
Robert S Langer
Newton
MA, US
Charles B Berde
Brookline
MA, US
Agent
Arnall Golden & Gregory
Assignee
Children s Medical Center Corporation
MA, US
IPC
A61K 9/22
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