05616334 is referenced by 27 patents and cites 43 patents.

Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.

Title
Low toxicity drug-lipid systems
Application Number
22157
Publication Number
5616334
Application Date
April 28, 1995
Publication Date
April 1, 1997
Inventor
Joel Portnoff
Richboro
PA, US
Robert Klimchak
Flemington
NJ, US
Anthony G Durning
Yardley
PA, US
John J Kearns
Princeton
NJ, US
Robert P Lenk
Lambertville
NJ, US
Pieter R Cullis
Vancouver
CA
Thomas D Madden
Vancouver
CA
Lawrence Boni
Monmouth Junction
NJ, US
Andrew S Janoff
Yardley
PA, US
Agent
Kenneth B Rubin
Assignee
The Liposome Company
NJ, US
IPC
A61K 9/00
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