05605662 is referenced by 625 patents and cites 25 patents.

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micromachining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific microlocations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.

Title
Active programmable electronic devices for molecular biological analysis and diagnostics
Application Number
8/146504
Publication Number
5605662
Application Date
November 1, 1993
Publication Date
February 25, 1997
Inventor
Eugene Tu
San Diego
CA, US
Michael J Heller
Encinitas
CA, US
Agent
Lyon & Lyon
Assignee
Nanogen
CA, US
IPC
C07H 21/04
C07H 21/02
C12Q 1/68
C12M 1/40
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