05603351 is referenced by 327 patents and cites 10 patents.

A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate comprises a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.

Title
Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
Application Number
8/483331
Publication Number
5603351
Application Date
June 7, 1995
Publication Date
February 18, 1997
Inventor
Peter J Zanzucchi
West Windsor Township, Mercer, County
NJ, US
Sterling E McBride
Lawrence Township, Mercer County
NJ, US
Aaron W Levine
Lawrenceville
NJ, US
Zhong H Fan
Middlesex
NJ, US
Robert R Demers
Cranbury
NJ, US
Satyam C Cherukuri
Cranbury
NJ, US
Agent
William J Burke
Assignee
David Sarnoff Research Center
NJ, US
IPC
C25B 15/08
F17D 1/20
F17D 1/14
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