05602240 is referenced by 525 patents and cites 14 patents.

Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --NR--C(O)--R--CH.sub.2, and CH.sub.2 --C(S)--NR--CH.sub.2. Methods for preparing and using these oligonucleotide analogs are also provided.

Title
Backbone modified oligonucleotide analogs
Application Number
558663
Publication Number
5602240
Application Date
April 25, 1994
Publication Date
February 11, 1997
Inventor
Phillip D Cook
Carlsbad
CA, US
Adrian Waldner
Allschwil
CH
Jacques Lebreton
Marseilles
FR
Alain De Mesmaeker
Kaenerkinden
CH
Agent
Woodcock Washburn Kurtz Mackiewicz & Norris
Assignee
Isis Pharmaceuticals
CA, US
Ciba Geigy
CH
IPC
C12N 15/11
C07H 21/00
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