05593852 is referenced by 1122 patents and cites 15 patents.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Title
Subcutaneous glucose electrode
Application Number
161682
Publication Number
5593852
Application Date
September 1, 1994
Publication Date
January 14, 1997
Inventor
Michael V Pishko
4304C Duval Rd., Austin, 78759
TX, US
Adam Heller
5317 Valburn Cir., Austin, 78731
TX, US
Agent
Merchant Gould Smith Edell Welter & Schmidt P A
IPC
G01N 33/48
C12Q 1/26
C12Q 1/54
C12Q 1/00
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