05589136 is referenced by 311 patents and cites 6 patents.

A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

Title
Silicon-based sleeve devices for chemical reactions
Application Number
8/492678
Publication Number
5589136
Application Date
June 20, 1995
Publication Date
December 31, 1996
Inventor
Joseph W Balch
Livermore
CA, US
Anthony V Carrano
Livermore
CA, US
Raymond P Mariella Jr
Danville
CA, US
M Allen Northrup
Berkeley
CA, US
Agent
L E Carnahan
Henry P Sartorio
Assignee
Regents of the University of California
CA, US
IPC
B01L 3/00
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